Grb2 Promotes Integrin-Induced Focal Adhesion Kinase (FAK) Autophosphorylation and Directs the Phosphorylation of Protein Tyrosine Phosphatase α by the Src-FAK Kinase Complex

The integrin-activated Src-focal adhesion kinase (FAK) kinase complex phosphorylates PTPα at Tyr789, initiating PTPα-mediated signaling that promotes cell migration. Recruitment of the BCAR3-Cas complex by PTPα-phospho-Tyr789 at focal adhesions is one mechanism of PTPα signaling. The adaptor protein...

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Bibliographic Details
Main Authors: Cheng, Suzanne Y. S., Sun, Guobin, Schlaepfer, David D., Pallen, Catherine J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911518/
https://ncbi.nlm.nih.gov/pubmed/24248601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00825-13
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