Immunoglobulin gene rearrangements and deletions in human Epstein-Barr virus-transformed cell lines producing different IgG and IgA subclasses.

During differentiation B lymphocytes may switch from the expression of surface IgM to the synthesis of IgG, IgA, or IgE isotypes by using a different heavy chain constant region (CH) gene. The molecular mechanisms by which switching occurs remain controversial. Rearrangements and deletions of CH gen...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Webb, C F, Cooper, M D, Burrows, P D, Griffin, J A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1985
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391149/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2991929/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.16.5495
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