Reversible Lipid Accumulation and Associated Division Arrest of Mycobacterium avium in Lipoprotein-Induced Foamy Macrophages May Resemble Key Events during Latency and Reactivation of Tuberculosis

During the dormant phase of tuberculosis, Mycobacterium tuberculosis persists in lung granulomas by residing in foamy macrophages (FM) that contain abundant lipid bodies (LB) in their cytoplasm, allowing bacilli to accumulate lipids as intracytoplasmic lipid inclusions (ILI). An experimental model o...

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Detalhes bibliográficos
Main Authors: Caire-Brändli, Irène, Papadopoulos, Alexia, Malaga, Wladimir, Marais, David, Canaan, Stéphane, Thilo, Lutz, de Chastellier, Chantal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911402/
https://ncbi.nlm.nih.gov/pubmed/24478064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01196-13
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