Antibodies to a Single, Conserved Epitope in Anopheles APN1 Inhibit Universal Transmission of Plasmodium falciparum and Plasmodium vivax Malaria

Malaria transmission-blocking vaccines (TBVs) represent a promising approach for the elimination and eradication of this disease. AnAPN1 is a lead TBV candidate that targets a surface antigen on the midgut of the obligate vector of the Plasmodium parasite, the Anopheles mosquito. In this study, we d...

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Detalhes bibliográficos
Main Authors: Armistead, Jennifer S., Morlais, Isabelle, Mathias, Derrick K., Jardim, Juliette G., Joy, Jaimy, Fridman, Arthur, Finnefrock, Adam C., Bagchi, Ansu, Plebanski, Magdalena, Scorpio, Diana G., Churcher, Thomas S., Borg, Natalie A., Sattabongkot, Jetsumon, Dinglasan, Rhoel R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911399/
https://ncbi.nlm.nih.gov/pubmed/24478095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01222-13
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