Key Role of Toll-Like Receptor 2 in the Inflammatory Response and Major Histocompatibility Complex Class II Downregulation in Brucella abortus-Infected Alveolar Macrophages

Alveolar macrophages (AM) seem to constitute the main cellular target of inhaled brucellae. Here, we show that Brucella abortus invades and replicates in murine AM without inducing cytotoxicity. B. abortus infection induced a statistically significant increase of tumor necrosis factor alpha (TNF-α),...

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Autori principali: Ferrero, Mariana C., Hielpos, M. Soledad, Carvalho, Natalia B., Barrionuevo, Paula, Corsetti, Patricia P., Giambartolomei, Guillermo H., Oliveira, Sergio C., Baldi, Pablo C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911380/
https://ncbi.nlm.nih.gov/pubmed/24478078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01237-13
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