Deregulation of Feedback Inhibition of Phosphoenolpyruvate Carboxylase for Improved Lysine Production in Corynebacterium glutamicum

Allosteric regulation of phosphoenolpyruvate carboxylase (PEPC) controls the metabolic flux distribution of anaplerotic pathways. In this study, the feedback inhibition of Corynebacterium glutamicum PEPC was rationally deregulated, and its effect on metabolic flux redistribution was evaluated. Based...

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Main Authors: Chen, Zhen, Bommareddy, Rajesh Reddy, Frank, Doinita, Rappert, Sugima, Zeng, An-Ping
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Biotechnology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911046/
https://ncbi.nlm.nih.gov/pubmed/24334667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03535-13
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