Efficient Activation of Human T Cells of Both CD4 and CD8 Subsets by Urease-Deficient Recombinant Mycobacterium bovis BCG That Produced a Heat Shock Protein 70-M. tuberculosis-Derived Major Membrane Protein II Fusion Protein

For the purpose of obtaining Mycobacterium bovis bacillus Calmette-Guérin (BCG) capable of activating human naive T cells, urease-deficient BCG expressing a fusion protein composed of Mycobacterium tuberculosis-derived major membrane protein II (MMP-II) and heat shock protein 70 (HSP70) of BCG (BCG-...

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Autores principales: Mukai, Tetsu, Tsukamoto, Yumiko, Maeda, Yumi, Tamura, Toshiki, Makino, Masahiko
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910920/
https://ncbi.nlm.nih.gov/pubmed/24152387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00564-13
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