Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

The cysteine protease cruzipain is essential for the viability, infectivity, and virulence of Trypanosoma cruzi, the causative agent of Chagas disease. Thus, inhibitors of cruzipain are considered promising anti-T. cruzi chemotherapeutic agents. Reversible cruzipain inhibitors containing a nitrile “...

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Autors principals: Ndao, Momar, Beaulieu, Christian, Black, W. Cameron, Isabel, Elise, Vasquez-Camargo, Fabio, Nath-Chowdhury, Milli, Massé, Frédéric, Mellon, Christophe, Methot, Nathalie, Nicoll-Griffith, Deborah A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910870/
https://ncbi.nlm.nih.gov/pubmed/24323474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01855-13
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