An NF-κB-Based High-Throughput Screen Identifies Piericidins as Inhibitors of the Yersinia pseudotuberculosis Type III Secretion System

The type III secretion system (T3SS) is a bacterial appendage used by dozens of Gram-negative pathogens to subvert host defenses and cause disease, making it an ideal target for pathogen-specific antimicrobials. Here, we report the discovery and initial characterization of two related natural produc...

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Detalhes bibliográficos
Main Authors: Duncan, Miles C., Wong, Weng Ruh, Dupzyk, Allison J., Bray, Walter M., Linington, Roger G., Auerbuch, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910828/
https://ncbi.nlm.nih.gov/pubmed/24295981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02025-13
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