A Combination Microbicide Gel Protects Macaques Against Vaginal Simian Human Immunodeficiency Virus-Reverse Transcriptase Infection, But Only Partially Reduces Herpes Simplex Virus-2 Infection After a Single High-Dose Cochallenge

Herpes simplex virus-2 (HSV-2) infection increases HIV susceptibility. We previously established a rhesus macaque model of vaginal HSV-2 preexposure followed by cochallenge with HSV-2 and simian/human immunodeficiency virus-reverse transcriptase (SHIV-RT). Using this model, we showed that a gel cont...

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Detalhes bibliográficos
Main Authors: Hsu, Mayla, Aravantinou, Meropi, Menon, Radhika, Seidor, Samantha, Goldman, Daniel, Kenney, Jessica, Derby, Nina, Gettie, Agegnehu, Blanchard, James, Piatak, Michael, Lifson, Jeffrey D., Fernández-Romero, Jose A., Zydowsky, Thomas M., Robbiani, Melissa
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910668/
https://ncbi.nlm.nih.gov/pubmed/24117013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2013.0165
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