The Somatic Genomic Landscape of Glioblastoma

We describe the landscape of somatic genomic alterations based on multi-dimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors including EGFR and PDGFRA. TERT promote...

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Detalhes bibliográficos
Main Authors: Brennan, Cameron W., Verhaak, Roel G.W., McKenna, Aaron, Campos, Benito, Noushmehr, Houtan, Salama, Sofie R., Zheng, Siyuan, Chakravarty, Debyani, Sanborn, J. Zachary, Berman, Samuel H., Beroukhim, Rameen, Bernard, Brady, Wu, Chang-Jiun, Genovese, Giannicola, Shmulevich, Ilya, Barnholtz-Sloan, Jill, Zou, Lihua, Vegesna, Rahulsimham, Shukla, Sachet A., Ciriello, Giovanni, Yung, WK, Zhang, Wei, Sougnez, Carrie, Mikkelsen, Tom, Aldape, Kenneth, Bigner, Darell D., Van Meir, Erwin G., Prados, Michael, Sloan, Andrew, Black, Keith L., Eschbacher, Jennifer, Finocchiaro, Gaetano, Friedman, William, Andrews, David W., Guha, Abhijit, Iacocca, Mary, O’Neill, Brian P., Foltz, Greg, Myers, Jerome, Weisenberger, Daniel J., Penny, Robert, Kucherlapati, Raju, Perou, Charles M., Hayes, D. Neil, Gibbs, Richard, Marra, Marco, Mills, Gordon B., Lander, Eric, Spellman, Paul, Wilson, Richard, Sander, Chris, Weinstein, John, Meyerson, Matthew, Gabriel, Stacey, Laird, Peter W., Haussler, David, Getz, Gad, Chin, Lynda
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910500/
https://ncbi.nlm.nih.gov/pubmed/24120142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.034
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