Gene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A(3) adenosine receptors

OBJECTIVE: An increased expression of adenosine receptors is a promising target for gene therapy aimed at protecting the myocardium against ischemic damage, but may alter cardiac electrophysiology. We therefore studied the effects of heart-directed overexpression of A(3) adenosine receptors (A(3)ARs...

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Autores principales: Fabritz, Larissa, Kirchhof, Paulus, Fortmüller, Lisa, Auchampach, John A., Baba, Hideo A., Breithardt, Günter, Neumann, Joachim, Boknik, Peter, Schmitz, Wilhelm
Formato: Artigo
Lenguaje:Inglês
Publicado: 2004
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910327/
https://ncbi.nlm.nih.gov/pubmed/15158142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cardiores.2004.02.004
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