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Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation

Learning is accompanied by modulation of postsynaptic signal transduction pathways in neurons. Although the neuronal protein kinase cyclin-dependent kinase 5 (Cdk5) has been implicated in cognitive disorders, its role in learning has been obscured by the perinatal lethality of constitutive knockout...

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Detalhes bibliográficos
Main Authors: Hawasli, Ammar H, Benavides, David R, Nguyen, Chan, Kansy, Janice W, Hayashi, Kanehiro, Chambon, Pierre, Greengard, Paul, Powell, Craig M, Cooper, Donald C, Bibb, James A
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910113/
https://ncbi.nlm.nih.gov/pubmed/17529984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn1914
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