Reduced Alzheimer’s disease pathology by St. John’s wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice

Soluble β-amyloid peptides (Aβ) and small Aβ oligomers represent the most toxic peptide moieties recognized in brains affected by Alzheimer’s disease (AD). Here we provide the first evidence that specific St. John’s wort (SJW) extracts both attenuate Aβ-induced histopathology and alleviate memory im...

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Main Authors: Hofrichter, Jacqueline, Krohn, Markus, Schumacher, Toni, Lange, Cathleen, Feistel, Björn, Walbroel, Bernd, Heinze, Hans-Jochen, Crockett, Sara, Sharbel, Timothy F., Pahnke, Jens
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909922/
https://ncbi.nlm.nih.gov/pubmed/24156265
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