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Simultaneous prediction of binding free energy and specificity for PDZ domain-peptide interactions

Interactions between protein domains and linear peptides underlie many biological processes. Among these interactions, the recognition of C-terminal peptides by PDZ domains is one of the most ubiquitous. In this work, we present a mathematical model for PDZ domain-peptide interactions capable of pre...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Crivelli, Joseph J., Lemmon, Gordon, Kaufmann, Kristian W., Meiler, Jens
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909503/
https://ncbi.nlm.nih.gov/pubmed/24305904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-013-9696-9
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