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A thermodynamic assay to test pharmacological chaperones for Fabry disease()
BACKGROUND: The majority of the disease-causing mutations affect protein stability, but not functional sites and are amenable, in principle, to be treated with pharmacological chaperones. These drugs enhance the thermodynamic stability of their targets. Fabry disease, a disorder caused by mutations...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Pub. Co
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3909460/ https://ncbi.nlm.nih.gov/pubmed/24361605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2013.12.018 |
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