Differential Modulation of Arcuate Nucleus and Mesolimbic Gene Expression Levels by Central Leptin in Rats on Short-Term High-Fat High-Sugar Diet

OBJECTIVE: Leptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high-sugar (fcHFHS) diet are resistant to peripherally administered leptin. The aim of this study was to investigate feeding responses to central leptin as well as the associated changes in mRNA levels in hy...

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Main Authors: van den Heuvel, José K., Eggels, Leslie, Fliers, Eric, Kalsbeek, Andries, Adan, Roger A. H., la Fleur, Susanne E.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909349/
https://ncbi.nlm.nih.gov/pubmed/24498181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087729
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