Flame Retardant BDE-47 Effectively Activates Nuclear Receptor CAR in Human Primary Hepatocytes

Polybrominated diphenyl ether BDE-47 (2,2′,4,4′-tetrabromodiphenyl ether) is a thyroid hormone disruptor in mice; hepatic induction of various metabolic enzymes and transporters has been suggested as the mechanism for this disruption. Utilizing Car (−/−) and Pxr (−/−) mice as well as human primary h...

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Hauptverfasser: Sueyoshi, Tatsuya, Li, Linhao, Wang, Hongbing, Moore, Rick, Kodavanti, Prasada Rao S., Lehmler, Hans-Joachim, Negishi, Masahiko, Birnbaum, Linda S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908718/
https://ncbi.nlm.nih.gov/pubmed/24218150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft243
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