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Detecting overlapping protein complexes in PPI networks based on robustness

BACKGROUND: Recently, large data sets of protein-protein interactions (PPI) which can be modeled as PPI networks are generated through high-throughput methods. And locally dense regions in PPI networks are very likely to be protein complexes. Since protein complexes play a key role in many biologica...

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Detalhes bibliográficos
Main Authors: Wang, Shuliang, Wu, Fang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908676/
https://ncbi.nlm.nih.gov/pubmed/24565162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5956-11-S1-S18
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