Immunization of rabbits with purified RNA polymerase I induces a distinct population of antibodies against nucleic acids as well as anti-RNA polymerase I antibodies, both characteristic of systemic lupus erythematosus.

Rabbits were immunized with either RNA polymerase I or poly(A) polymerase that had been purified to apparent homogeneity and was devoid of nucleic acids. Sera from rabbits thus immunized were screened for antibodies against nucleic acids. All seven rabbits injected with RNA polymerase I but none of...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Stetler, D A, Jacob, S T
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1985
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390774/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3863129/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.20.6797
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