Preeclampsia Is Associated with Alterations in the p53-Pathway in Villous Trophoblast

BACKGROUND: Preeclampsia (PE) is characterized by exaggerated apoptosis of the villous trophoblast of placental villi. Since p53 is a critical regulator of apoptosis we hypothesized that excessive apoptosis in PE is mediated by abnormal expression of proteins participating in the p53 pathway and tha...

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Main Authors: Sharp, Andrew N., Heazell, Alexander E. P., Baczyk, Dora, Dunk, Caroline E., Lacey, Helen A., Jones, Carolyn J. P., Perkins, Jonathan E., Kingdom, John C. P., Baker, Philip N., Crocker, Ian P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907567/
https://ncbi.nlm.nih.gov/pubmed/24498154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087621
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