Preeclampsia Is Associated with Alterations in the p53-Pathway in Villous Trophoblast

BACKGROUND: Preeclampsia (PE) is characterized by exaggerated apoptosis of the villous trophoblast of placental villi. Since p53 is a critical regulator of apoptosis we hypothesized that excessive apoptosis in PE is mediated by abnormal expression of proteins participating in the p53 pathway and tha...

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Autori principali: Sharp, Andrew N., Heazell, Alexander E. P., Baczyk, Dora, Dunk, Caroline E., Lacey, Helen A., Jones, Carolyn J. P., Perkins, Jonathan E., Kingdom, John C. P., Baker, Philip N., Crocker, Ian P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907567/
https://ncbi.nlm.nih.gov/pubmed/24498154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087621
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