Plasmacytoid Dendritic Cell Dynamics Tune Interferon-Alfa Production in SIV-Infected Cynomolgus Macaques

IFN-I production is a characteristic of HIV/SIV primary infections. However, acute IFN-I plasma concentrations rapidly decline thereafter. Plasmacytoid dendritic cells (pDC) are key players in this production but primary infection is associated with decreased responsiveness of pDC to TLR 7 and 9 tri...

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Bibliographic Details
Main Authors: Bruel, Timothée, Dupuy, Stéphanie, Démoulins, Thomas, Rogez-Kreuz, Christine, Dutrieux, Jacques, Corneau, Aurélien, Cosma, Antonio, Cheynier, Rémi, Dereuddre-Bosquet, Nathalie, Le Grand, Roger, Vaslin, Bruno
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907389/
https://ncbi.nlm.nih.gov/pubmed/24497833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003915
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