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NAD as a Genotype-Specific Drug Target
Using high throughput chemical and genetic screening, STF-118804, an inhibitor of nicotinamide phosphoribosyltransferase, was identified as a cell type-specific inhibitor of mixed-lineage leukemia with MLL chromosomal rearrangements (Matheny et al., 2013). The approach was powerful as is the potenti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3907267/ https://ncbi.nlm.nih.gov/pubmed/24267273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.11.001 |
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