Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer by Analysis of Second Harmonic Generation Polarization and Emission Directionality

A profound remodeling of the extracellular matrix occurs in many epithelial cancers. In ovarian cancer, the minor collagen isoform of Col III becomes upregulated in invasive disease. Here we use second harmonic generation (SHG) imaging microscopy to probe structural differences in fibrillar models o...

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Bibliografiske detaljer
Main Authors: Tilbury, Karissa, Lien, Chi-Hsiang, Chen, Shean-Jen, Campagnola, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2014
Fag:
Cell Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907237/
https://ncbi.nlm.nih.gov/pubmed/24461010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.10.044
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