The monomeric alpha beta form of the insulin receptor exhibits much higher insulin-dependent tyrosine-specific protein kinase activity than the intact alpha 2 beta 2 form of the receptor.
The relationship between the structure of the insulin receptor and its kinase activity was studied on the purified receptor treated with different concentrations of dithiothreitol. An enhanced autophosphorylation of the beta subunit (Mr, 90,000) was observed on NaDodSO4/PAGE under reducing condition...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1985
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390706/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2412229/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.18.6095 |
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