A new pharmacological role for donepezil: attenuation of morphine-induced tolerance and apoptosis in rat central nervous system

BACKGROUND: Tolerance to the analgesic effect of opioids is a pharmacological phenomenon that occurs after their prolonged administration. It has been shown that morphine-induced tolerance is associated with apoptosis in the central nervous system and neuroprotective agents which prevented apoptosis...

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Detalhes bibliográficos
Main Authors: Sharifipour, Mozhdeh, Izadpanah, Esmaeal, Nikkhoo, Bahram, Zare, Samad, Abdolmaleki, Ali, Hassanzadeh, Katayoun, Moradi, Farshid, Hassanzadeh, Kambiz
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906771/
https://ncbi.nlm.nih.gov/pubmed/24455992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-21-6
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