Rapid optical control of nociception with an ion channel photoswitch

Local anesthetics are effective in suppressing pain sensation, but most of these compounds act non-selectively, inhibiting the activity of all neurons. Moreover, their actions abate slowly, preventing precise spatial and temporal control of nociception. We have developed a photoisomerizable molecule...

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Bibliografiske detaljer
Main Authors: Mourot, Alexandre, Fehrentz, Timm, Feuvre, Yves Le, Smith, Caleb M., Herold, Christian, Dalkara, Deniz, Nagy, Frédéric, Trauner, Dirk, Kramer, Richard H.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906498/
https://ncbi.nlm.nih.gov/pubmed/22343342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1897
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