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microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts

Polycomb group protein BMI1 is an important regulator of senescence, aging, and cancer. On one hand, it is overexpressed in cancer cells and is required for self-renewal of stem cells. On the other hand, it is downregulated during senescence and aging. MicroRNAs have emerged as major regulators of a...

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Main Authors: Dimri, Manjari, Carroll, Jeremy D, Cho, Joon-Ho, Dimri, Goberdhan P
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906339/
https://ncbi.nlm.nih.gov/pubmed/24091627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26592
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