Reprogramming of non-genomic estrogen signaling by the stemness factor SOX2 enhances the tumor-initiating capacity of breast cancer cells

The restoration of pluripotency circuits by the reactivation of endogenous stemness factors, such as SOX2, may provide a new paradigm in cancer development. The tumoral stem cell reprogramming hypothesis, i.e., the ability of stemness factors to redirect normal and differentiated tumor cells toward...

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Main Authors: Vazquez-Martin, Alejandro, Cufí, Sílvia, López-Bonet, Eugeni, Corominas-Faja, Bruna, Cuyàs, Elisabet, Vellon, Luciano, Iglesias, Juan Manuel, Leis, Olatz, Martín, Ángel G, Menendez, Javier A
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906332/
https://ncbi.nlm.nih.gov/pubmed/24107627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26692
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