Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death

Activation of Checkpoint kinase 1 (Chk1) following DNA damage mediates cell cycle arrest to prevent cells with damaged DNA from entering mitosis. Here we provide a high-resolution analysis of cells as they undergo S- and G₂-checkpoint bypass in response to Chk1 inhibition with the selective Chk1 inh...

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Detalhes bibliográficos
Main Authors: Del Nagro, Christopher J, Choi, Jonathan, Xiao, Yang, Rangell, Linda, Mohan, Sankar, Pandita, Ajay, Zha, Jiping, Jackson, Peter K, O’Brien, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906246/
https://ncbi.nlm.nih.gov/pubmed/24247149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27055
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