Simvastatin Impairs Growth Hormone-Activated Signal Transducer and Activator of Transcription (STAT) Signaling Pathway in UMR-106 Osteosarcoma Cells

Recent studies have demonstrated that statins reduce cell viability and induce apoptosis in various types of cancer cells. The molecular mechanisms underlying these effects are poorly understood. The JAK/STAT pathway plays an important role in the regulation of proliferation and apoptosis in many ti...

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Detalhes bibliográficos
Main Authors: Sandoval-Usme, María Claudia, Umaña-Pérez, Adriana, Guerra, Borja, Hernández-Perera, Orlando, García-Castellano, José Manuel, Fernández-Pérez, Leandro, Sánchez-Gómez, Myriam
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906206/
https://ncbi.nlm.nih.gov/pubmed/24489959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087769
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