Novel Marker for the Onset of Frontotemporal Dementia: Early Increase in Activity-Dependent Neuroprotective Protein (ADNP) in the Face of Tau Mutation

Tauopathy, a major pathology in Alzheimer's disease, is also found in ∼50% of frontotemporal dementias (FTDs). Tau transcript, a product of a single gene, undergoes alternative splicing to yield 6 protein species, each with either 3 or 4 microtubule binding repeat domains (tau 3R or 4R, associa...

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Main Authors: Schirer, Yulie, Malishkevich, Anna, Ophir, Yotam, Lewis, Jada, Giladi, Eliezer, Gozes, Illana
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906161/
https://ncbi.nlm.nih.gov/pubmed/24489906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087383
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