Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.

DDT1 MF-2 cells, which are derived from hamster vas deferens smooth muscle, contain alpha 1-adrenergic receptors (54,800 +/- 2700 sites per cell) that are coupled to stimulation of inositol phospholipid metabolism. Incubation of these cells with tumor-promoting phorbol esters, which stimulate calciu...

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Detalhes bibliográficos
Main Authors: Leeb-Lundberg, L M, Cotecchia, S, Lomasney, J W, DeBernardis, J F, Lefkowitz, R J, Caron, M G
Formato: Artigo
Idioma:Inglês
Publicado em: 1985
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC390609/
https://ncbi.nlm.nih.gov/pubmed/2994039
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