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Use of Size and a Co-polymer Design Feature to Improve the Biodistribution and the Enhanced Permeability and Retention Effect of Doxorubicin-loaded Mesoporous Silica Nanoparticles in a Murine Xenograft Tumor Model
A key challenge for improving the efficacy of passive drug delivery to tumor sites by a nanocarrier is to limit reticuloendothelial system (RES) uptake and to maximize the enhanced permeability and retention (EPR) effect. We demonstrate that size reduction and surface functionalization of mesoporous...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905975/ https://ncbi.nlm.nih.gov/pubmed/21524062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn200809t |
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