Loss of the nucleosome-binding protein HMGN1 affects the rate of N-nitrosodiethylamine induced hepatocarcinogenesis in mice

We report that HMGN1, a nucleosome binding protein that affects chromatin structure and function, affects the growth of N-nitrosodiethylamine (DEN) induced liver tumors. Following a single DEN injection at 2 weeks of age, Hmgn1(tm1/tm1) mice, lacking the nucleosome-binding domain of HMGN1, had earli...

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Bibliographic Details
Main Authors: Postnikov, Yuri V., Furusawa, Takashi, Haines, Diana C., Factor, Valentina M., Bustin, Michael
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905959/
https://ncbi.nlm.nih.gov/pubmed/24296759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0392
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