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The Nucleosome Binding Protein HMGN3 Modulates the Transcription Profile of Pancreatic β Cells and Affects Insulin Secretion
Improper glucose-stimulated insulin secretion from pancreatic β cells is a major factor in the onset of type 2 diabetes. We now report that HMGN3, a nuclear protein that binds to nucleosomes and affects chromatin function, is highly expressed in β cells and that in mice, loss of HMGN3 impairs glucos...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747976/ https://ncbi.nlm.nih.gov/pubmed/19651901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00526-09 |
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