New Mechanisms to Explain the Effects of Added Lactose Fines on the Dispersion Performance of Adhesive Mixtures for Inhalation

Fine excipient particles or ‘fines’ have been shown to improve the dispersion performance of carrier-based formulations for dry powder inhalation. Mechanistic formulation studies have focussed mainly on explaining this positive effect. Previous studies have shown that higher drug contents may cause...

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Главные авторы: Grasmeijer, Floris, Lexmond, Anne J., van den Noort, Maarten, Hagedoorn, Paul, Hickey, Anthony J., Frijlink, Henderik W., de Boer, Anne H.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905031/
https://ncbi.nlm.nih.gov/pubmed/24489969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087825
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