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New Mechanisms to Explain the Effects of Added Lactose Fines on the Dispersion Performance of Adhesive Mixtures for Inhalation

Fine excipient particles or ‘fines’ have been shown to improve the dispersion performance of carrier-based formulations for dry powder inhalation. Mechanistic formulation studies have focussed mainly on explaining this positive effect. Previous studies have shown that higher drug contents may cause...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Grasmeijer, Floris, Lexmond, Anne J., van den Noort, Maarten, Hagedoorn, Paul, Hickey, Anthony J., Frijlink, Henderik W., de Boer, Anne H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905031/
https://ncbi.nlm.nih.gov/pubmed/24489969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087825
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