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High-resolution Xist binding maps reveal 2-step spreading during X-inactivation
The Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which mammals compensate for unequal numbers of sex chromosomes(1-3). During XCI, Xist coats the future inactive X (Xi)(4) and recruits Polycomb Repressive Complex 2 (PRC2) to the X-inactivation cen...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904790/ https://ncbi.nlm.nih.gov/pubmed/24162848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12719 |
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