ATTENUATION OF EXPRESSION OF EXTRACELLULAR MATRIX GENES WITH SIRNAS TO SPARC AND CTGF IN SKIN FIBROBLASTS OF CTGF TRANSGENIC MICE

Transgenic mice that over-express connective tissue growth factor (CTGF) in fibroblasts under the control of an enhancer/promoter element of the Colla2 gene (Col1a2-CTGF) recapitulate multiorgan fibrosis similar to fibrosis observed in Scleroderma (SSc). In this study we investigate the regulation o...

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Main Authors: WANG, J.C., SONNYLAL, S., ARNETT, F.C., DE CROMBRUGGHE, B., ZHOU, X.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904509/
https://ncbi.nlm.nih.gov/pubmed/21978691
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