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Structure-based approach to alter the substrate specificity of Bacillus subtilis aminopeptidase
Aminopeptidases can selectively catalyze the cleavage of the N-terminal amino acid residues from peptides and proteins. Bacillus subtilis aminopeptidase (BSAP) is most active toward p-nitroanilides (pNAs) derivatives of Leu, Arg, and Lys. The BSAP with broad substrate specificity is expected to impr...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904319/ https://ncbi.nlm.nih.gov/pubmed/23787698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.25147 |
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