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Detection of QTc interval prolongation using jacket telemetry in conscious non-human primates: comparison with implanted telemetry
Background and Purpose: During repeat-dose toxicity studies, ECGs are collected from chemically or physically-restrained animals over a short timeframe. This is problematic due to cardiovascular changes caused by manual restraint stress and anesthesia, and limited ECG sampling. These factors confoun...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
The British Pharmacological Society
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904268/ https://ncbi.nlm.nih.gov/pubmed/24372552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12484 |
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