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Taking the long view: how to design a series of Phase III trials to maximize cumulative therapeutic benefit

BACKGROUND: Traditional clinical trial designs strive to definitively establish the superiority of an experimental treatment, which results in risk-adverse criteria and large sample sizes. Increasingly, common cancers are recognized as consisting of small subsets with specific aberrations for target...

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Bibliographic Details
Main Authors: Le Deley, Marie-Cécile, Ballman, Karla V, Marandet, Julien, Sargent, Daniel
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904223/
https://ncbi.nlm.nih.gov/pubmed/22569743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774512443430
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