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Taking the long view: how to design a series of Phase III trials to maximize cumulative therapeutic benefit
BACKGROUND: Traditional clinical trial designs strive to definitively establish the superiority of an experimental treatment, which results in risk-adverse criteria and large sample sizes. Increasingly, common cancers are recognized as consisting of small subsets with specific aberrations for target...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904223/ https://ncbi.nlm.nih.gov/pubmed/22569743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774512443430 |
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