Evaluation of Hyperpolarized [1-(13)C]-Pyruvate by Magnetic Resonance to Detect Ionizing Radiation Effects in Real Time

Ionizing radiation (IR) cytotoxicity is primarily mediated through reactive oxygen species (ROS). Since tumor cells neutralize ROS by utilizing reducing equivalents, we hypothesized that measurements of reducing potential using real-time hyperpolarized (HP) magnetic resonance spectroscopy (MRS) and...

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Autori principali: Sandulache, Vlad C., Chen, Yunyun, Lee, Jaehyuk, Rubinstein, Ashley, Ramirez, Marc S., Skinner, Heath D., Walker, Christopher M., Williams, Michelle D., Tailor, Ramesh, Court, Laurence E., Bankson, James A., Lai, Stephen Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903593/
https://ncbi.nlm.nih.gov/pubmed/24475215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087031
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