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Translational regulation of BACE-1 expression in neuronal and non-neuronal cells

As the main beta-secretase of the central nervous system, BACE-1 is a key protein in the pathogenesis of Alzheimer’s disease. Excessive expression of the protein might cause an overproduction of the neurotoxic beta-amyloid peptide. Therefore, a tight regulation of BACE-1 expression is expected in vi...

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Detalhes bibliográficos
Main Authors: De Pietri Tonelli, Davide, Mihailovich, Marija, Di Cesare, Alessandra, Codazzi, Franca, Grohovaz, Fabio, Zacchetti, Daniele
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC390341/
https://ncbi.nlm.nih.gov/pubmed/15034149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh348
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