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Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8)
Ca(2+) flux through L-type Ca(V)1.2 channels shapes the waveform of the ventricular action potential (AP) and is essential for excitation-contraction (EC) coupling. Timothy syndrome (TS) is a disease caused by a gain-of-function mutation in the Ca(V)1.2 channel (Ca(V)1.2-TS) that decreases inactivat...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3903114/ https://ncbi.nlm.nih.gov/pubmed/24215710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.10.021 |
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