Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan

A transcriptional attenuation mechanism regulates expression of the bacterial tnaCAB operon. This mechanism requires ribosomal arrest induced by the regulatory nascent TnaC peptide in response to free L-tryptophan (L-Trp). In this study we demonstrate, using genetic and biochemical analyses, that in...

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Detalhes bibliográficos
Main Authors: Martínez, Allyson K., Gordon, Emily, Sengupta, Arnab, Shirole, Nitin, Klepacki, Dorota, Martinez-Garriga, Blanca, Brown, Lewis M., Benedik, Michael J., Yanofsky, Charles, Mankin, Alexander S., Vazquez-Laslop, Nora, Sachs, Matthew S., Cruz-Vera, Luis R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902921/
https://ncbi.nlm.nih.gov/pubmed/24137004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt923
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