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Coding-sequence determinants of gene expression in Escherichia coli

Synonymous mutations do not alter the encoded protein, but they can influence gene expression. To investigate the mechanisms, we engineered a synthetic library of 154 genes that vary randomly at synonymous sites, but all encode the same green fluorescent protein. When expressed in E. coli, GFP prote...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kudla, Grzegorz, Murray, Andrew W., Tollervey, David, Plotkin, Joshua B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902468/
https://ncbi.nlm.nih.gov/pubmed/19359587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1170160
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