Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK

BACKGROUND: The liver-specific glucokinase knockout (gck(w/–)) mouse experiences long-term hyperglycemia and insulin resistance. This study was designed to evaluate the functional and structural changes in the myocardium of 60 week-old gck(w/–) mice, and to investigate the effect of rosiglitazone on...

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Detalhes bibliográficos
Main Authors: Li, Hui, Wang, Xi, Mao, Yiqing, Hu, Ruobi, Xu, Wei, Lei, Zhen, Zhou, Na, Jin, Ling, Guo, Tingting, Li, Zhixin, Irwin, David M, Niu, Gang, Tan, Huanran
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901845/
https://ncbi.nlm.nih.gov/pubmed/24447392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-13-24
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