Identification of Tissue microRNAs Predictive of Sunitinib Activity in Patients with Metastatic Renal Cell Carcinoma

PURPOSE: To identify tissue microRNAs predictive of sunitinib activity in patients with metastatic renal-cell-carcinoma (MRCC) and to evaluate in vitro their mechanism of action in sunitinib resistance. METHODS: We screened 673 microRNAs using TaqMan Low-density-Arrays (TLDAs) in tumors from MRCC pa...

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Main Authors: Prior, Celia, Perez-Gracia, Jose Luis, Garcia-Donas, Jesus, Rodriguez-Antona, Cristina, Guruceaga, Elizabeth, Esteban, Emilio, Suarez, Cristina, Castellano, Daniel, del Alba, Aránzazu González, Lozano, Maria Dolores, Carles, Joan, Climent, Miguel Angel, Arranz, Jose Angel, Gallardo, Enrique, Puente, Javier, Bellmunt, Joaquim, Gurpide, Alfonso, Lopez-Picazo, Jose Maria, Hernandez, Alvaro Gonzalez, Mellado, Begoña, Martínez, Esther, Moreno, Fernando, Font, Albert, Calvo, Alfonso
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901669/
https://ncbi.nlm.nih.gov/pubmed/24475095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086263
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