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The gap junction blocker carbenoxolone attenuates nociceptive behavior and medullary dorsal horn central sensitization induced by partial infraorbital nerve transection in rats

Glial cells are being increasingly implicated in mechanisms underlying pathological pain and recent studies suggest glial gap junctions involving astrocytes may contribute. The aim of the present study was to examine the effect of a gap junction blocker carbenoxolone (CBX) on medullary dorsal horn (...

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Detalhes bibliográficos
Main Authors: Wang, Hua, Cao, Ye, Chiang, Chen-Yu, Dostrovsky, Jonathan O., Sessle, Barry J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901535/
https://ncbi.nlm.nih.gov/pubmed/24239671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.11.004
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